NAD+ IV Infusion
Nicotinamide Adenine Dinucleotide — the Coenzyme at the Center of Every Cell's Energy Production, DNA Repair, and Anti-Aging Pathway

Quick Benefit Highlights
- The Coenzyme Behind Every Cell’s Energy and Repair: NAD+ is required for over 500 enzymatic reactions in the body — including the reactions that produce ATP in the mitochondria, the reactions that repair damaged DNA, and the reactions that regulate the sirtuins and PARP enzymes now at the center of longevity science
- Levels Decline With Age — and IV Replacement Is the Most Impactful Way to Restore Them: NAD+ levels fall by approximately 50% between the ages of 40 and 60, and continue declining thereafter. This decline is directly linked to the reduced cellular repair capacity, metabolic inefficiency, and cognitive slowing that accompany aging. IV NAD+ raises serum levels immediately and significantly in a way that oral precursors cannot match for speed or magnitude
- A Breadth of Recognized Benefits Supported by Published Research: Clinical and preclinical evidence associates IV NAD+ with improvements in mental clarity, energy, mood, athletic performance, metabolic function, and recovery from addiction and long-COVID — a scope of benefit that reflects how fundamental NAD+ is to virtually every system in the body
- Four Dosages for Four Levels of Need: From the 250mg introductory dose to the 1000mg high-potency protocol, Vitality Infusions offers the full dosage range used in NAD+ therapy — so your protocol can be matched to your goals, your timeline, and your experience with the treatment
Every Cell in Your Body Runs on NAD+.
What Happens When You Start Running Low?
Nicotinamide adenine dinucleotide is not a vitamin or a supplement in the conventional sense. It is a coenzyme — a molecule that sits at the center of hundreds of biochemical reactions in every cell of the body, enabling them to occur. Without adequate NAD+, these reactions slow down, stall, or fail entirely. And unlike most nutrients, NAD+ declines not from dietary insufficiency alone but as a direct consequence of biological aging — with levels dropping by roughly half between the ages of 40 and 60 regardless of how well a person eats or lives.
The implications of this decline are broad and compounding. At the mitochondrial level, lower NAD+ means less efficient conversion of nutrients into ATP — the cellular energy currency that powers every process in the body. At the genomic level, lower NAD+ means slower activation of the PARP enzymes that detect and repair DNA strand breaks, allowing cellular damage to accumulate faster than it can be corrected. At the regulatory level, lower NAD+ means reduced activation of the sirtuins — a family of proteins that govern gene expression, stress response, inflammation control, and the biological aging rate itself. The result of all three declining simultaneously is what most people experience simply as getting older: lower energy, slower recovery, reduced cognitive sharpness, and a body that repairs itself less efficiently than it once did.
IV NAD+ administration bypasses the intestinal conversion steps required by oral NAD+ precursors like NMN and NR, delivering the active coenzyme directly into the bloodstream at concentrations that produce immediate cellular effects. The response many clients experience during and after their NAD+ infusion — a distinctive mental clarity, a sense of cellular aliveness, and an energy that feels fundamentally different from a caffeine or stimulant effect — reflects the direct biochemical impact of restoring the coenzyme the body’s most critical processes depend on.
NAD+ Has Been Found To:
- Reduce stress, depression, and anxiety through its role in neurotransmitter synthesis and sirtuin-mediated neuroprotection
- Improve post-COVID symptoms including brain fog, fatigue, and exercise intolerance by restoring mitochondrial energy production in depleted cells
- Improve mental clarity, alertness, concentration, and memory through the NAD+-dependent pathways that support neuronal function and synaptic health
- Increase metabolism and energy by restoring the efficiency of the mitochondrial reactions that produce ATP from nutrients
- Reduce symptoms of withdrawal from alcohol and certain substances by supporting the neurochemical repair processes that addiction depletes
- Reduce signs of aging by activating sirtuin-mediated DNA repair, reducing cellular oxidative damage, and supporting the telomere maintenance pathways associated with biological longevity
- Restore muscle function and athletic performance by improving mitochondrial energy availability and reducing the oxidative damage that impairs muscle cell repair
Ideal For:
- Adults over 35 who want to proactively address the NAD+ decline that accompanies aging before its effects become pronounced
- Anyone experiencing persistent fatigue, brain fog, or cognitive slowing that has not responded to standard wellness protocols
- Those managing post-COVID symptoms including long-haul fatigue, cognitive impairment, and reduced exercise capacity
- Athletes and high-performance individuals who want to optimize mitochondrial energy production and recovery at the cellular level
- Clients focused on longevity, cellular anti-aging, and the long-term protection of cognitive and physical function
- Those in recovery from alcohol or substance dependence who want neurochemical repair support as part of their protocol
- Anyone who has plateaued on conventional wellness approaches and wants to address the cellular energy and repair layer directly
How You’ll Feel:
NAD+ infusions are among the most distinctively experiential treatments on our menu. During the infusion itself, particularly at higher doses, clients commonly report a building sense of mental clarity, a subtle warmth or pressure in the chest that passes as the rate is adjusted, and a quality of aliveness that is difficult to describe but immediately recognizable. In the 24 to 72 hours following a session, clients consistently report sharper cognition, elevated and stable mood, significantly improved energy, and a sense of physical and mental restoration that accumulates with successive infusions. Many clients describe their first high-dose NAD+ infusion as one of the most impactful wellness experiences of their lives.
Service Details
What Is NAD+ and Why Is IV the Most Effective Way to Raise It?
NAD+ (nicotinamide adenine dinucleotide) exists in two forms — NAD+ (oxidized) and NADH (reduced) — and cycles between them as it carries electrons through the metabolic reactions that produce cellular energy. In its oxidized form, NAD+ accepts electrons from the breakdown of glucose and fatty acids in the citric acid cycle, becoming NADH. NADH then donates those electrons to the electron transport chain, where they drive the production of the vast majority of the body’s ATP. This cycle runs continuously in every mitochondrion in every cell — it is literally the biochemical engine of life.
Beyond energy production, NAD+ is the required substrate for three families of enzymes that are now central to aging and disease research. The sirtuins (SIRT1-7) are NAD+-dependent deacylases that regulate gene expression, mitochondrial biogenesis, stress response, and inflammation — they are among the most studied longevity regulators in biology. The PARP enzymes (poly-ADP ribose polymerases) use NAD+ to detect and repair DNA strand breaks caused by oxidative stress, radiation, and replication errors — their activity is directly dependent on available NAD+, and declining NAD+ levels are associated with accumulating genomic instability. The CD38 and CD157 enzymes consume NAD+ in calcium signaling and immune regulation pathways and are significant contributors to the NAD+ decline seen with aging and inflammation.
Oral NAD+ precursors like NMN (nicotinamide mononucleotide) and NR (nicotinamide riboside) must be absorbed through the intestine, converted in the liver, and transported to cells before contributing to cellular NAD+ pools — a multi-step process that takes hours and produces modest, gradual increases in serum and tissue NAD+. IV NAD+ delivers the coenzyme directly into the bloodstream, bypassing every conversion step and producing immediate, high-concentration plasma availability that cells throughout the body can access in real time. This is why IV NAD+ produces the distinctive acute experience that oral precursors do not — the physiological response is immediate and direct rather than gradual and metabolically mediated.
Choosing Your Dosage
NAD+ is offered in four dosages at Vitality Infusions. Selection depends on your goals, your experience with NAD+ therapy, and the time you have available for your session. Your nurse can help you choose at consultation.
250mg | Approx. 1–2 hours
The recommended starting dose for first-time NAD+ clients. Provides a meaningful introduction to the experience and benefit of IV NAD+ while allowing your body to acclimate to the infusion rate. Ideal for those new to NAD+ therapy, clients with schedule constraints, or those who want a maintenance dose between higher-dose sessions.
500mg | Approx. 2–3 hours
The most commonly selected dose for clients seeking significant cognitive, energy, and recovery benefits from a single session. Represents the entry point into the clinically meaningful range used in most NAD+ research protocols and is the most popular dosage among clients who have completed their first session.
750mg | Approx. 3–4 hours
A high-potency dose for clients who have experienced 500mg and want deeper cellular impact, or those managing specific concerns such as post-COVID recovery, significant cognitive decline, athletic optimization, or active neurochemical repair. Provides a substantially deeper and more sustained benefit than lower doses.
1000mg | Approx. 4 hours
The highest available dose at Vitality Infusions and the most intensive single-session NAD+ protocol we offer. Recommended for clients with prior NAD+ experience who are seeking maximum cellular repair and rejuvenation impact, those working through addiction recovery protocols, or clients who want the deepest possible neurological and mitochondrial restoration from a single appointment.
Published Research
Clients interested in the clinical and preclinical research supporting NAD+ therapy can review the following publications:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751327/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277084/Key Benefits
- Required coenzyme for ATP synthesis — restores the mitochondrial energy production efficiency that NAD+ decline impairs
- Activates sirtuin-mediated DNA repair, gene expression regulation, and anti-aging pathways
- Supports PARP enzyme activity for genomic stability and cellular repair under oxidative and metabolic stress
- Improves cognitive clarity, focus, and memory through neuronal NAD+-dependent signaling pathways
- Supports neurochemical repair in the context of addiction recovery and long-COVID neurological symptoms
- Restores muscle cell mitochondrial function for improved athletic performance and recovery
- IV delivery produces immediate plasma availability, bypassing the multi-step conversion required by oral NAD+ precursors
- Four dosage tiers allow personalized protocols from introductory to high-intensity cellular repair
Who Is It For?
NAD+ IV therapy is appropriate for any healthy adult seeking cellular energy, cognitive, anti-aging, recovery, or neurochemical support. It is the most advanced and most impactful single protocol on our menu and is appropriate for both first-time wellness clients and experienced IV therapy recipients. Clients in addiction recovery using NAD+ as part of a broader protocol should coordinate with their primary care or addiction medicine provider. Please consult your nurse if you have a history of active malignancy, as the proliferative signaling associated with sirtuin and PARP activation may require additional consideration in oncology contexts.
Important Notes and What to Expect During Your Infusion
NAD+ infusions are administered slowly to minimize the side effects associated with rapid infusion rates, which can include chest tightness, a sense of pressure, nausea, flushing, or muscle cramping. These sensations are temporary and rate-dependent — when they occur, your nurse will slow the infusion until they pass, then gradually increase the rate again. This is a normal part of NAD+ therapy and is not a sign of an adverse reaction. Higher doses require slower rates and longer session times. Plan your appointment on a day when you have adequate time and are not rushed. Most clients find the experience increasingly comfortable with successive sessions as the body acclimates.
Mobile appointments for NAD+ therapy may incur an additional fee if the session runs significantly longer than expected due to rate adjustments. Please discuss timing and the mobile fee policy with your nurse when booking. Results vary by individual. This product is not intended to diagnose, treat, cure, or prevent any disease.
What to Expect: Your Session
- Consultation and Dosage Selection: Your nurse reviews your health history, current goals, and any prior NAD+ experience to confirm the appropriate dosage for your session. First-time clients receive a full overview of what to expect during the infusion including the chest pressure sensation and how the infusion rate will be managed.
- Comfortable Setup: Settle into our heated massage chair or your mobile location. NAD+ sessions run longer than standard infusions — bring something to watch, read, or listen to. Your nurse places the IV catheter and begins the infusion at a rate appropriate for your dose.
- Your Infusion Session (1–4 Hours Depending on Dose): Your nurse monitors you closely throughout, particularly in the early stages of the infusion. If you experience chest pressure, flushing, or nausea, let your nurse know immediately and the rate will be reduced. Most clients find a comfortable rate within the first 45 minutes and the remainder of the session proceeds smoothly. Many report the distinctive clarity and aliveness of NAD+ building progressively as the session continues.
- Post-Infusion: Catheter out and you are free to go. Many clients experience the most significant benefit in the 24 to 48 hours following their session as NAD+ levels stabilize and cellular processes responding to the restored coenzyme pool begin to show results. Plan to be well-rested and well-hydrated in the day following your infusion.
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Our Process
Schedule a visit to our Ft. Myers lounge or order mobile delivery for premium IV therapy, customized for your health and wellness goals.
1. CONNECT
Find your nearest location and contact our team.
2. CHOOSE CARE
Choose your infusion and our registered nurses provide you with your IV.
3. RECEIVE CARE
The treatment is virtually painless and is typically 45 to 60 minutes for IV treatments or 5 minutes for IM injections.
4. ENJOY BENEFITS
Within minutes you are feeling great, Ready to enjoy your life to the fullest!
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